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Ankylosing spondylitis

Also called: Ankylosing spondylitis, axial spondyloarthritis

Inflammatory arthritis of the spine causing low back pain and stiffness that's worse in the morning and better with exercise, usually starting before age 45.

StartsBefore 45
PainBetter with movement, worse with rest
TreatmentNSAIDs, biologics, exercise

Overview

It can also cause eye inflammation (uveitis) and heel pain.

Symptoms

Common signs:

  • Low back pain and morning stiffness
  • Low back stiffness that improves with movement, in a younger adult

Less common

  • Heel pain
  • Eye pain
  • Tiredness

When to get medical care

Call 911This isn't an emergency by itself. Call 911 for trouble breathing, chest pain, or fainting.
Get care todayPainful red eye.
See a doctor soonBack pain over 3 months that improves with exercise.

Causes

Immune inflammation.

Does it spread or run in families?

  • It isn't contagious. You can't catch it from someone else.
  • It can run in families. Tell your doctor if a parent, brother, or sister has it.

Who is more likely to get it

  • Men
  • Family history

Possible complications

Diagnosis

Tests and imaging.

Questions you may be asked

  • Morning stiffness length

The exam

Spine motion.

Tests

Tests, if needed:

  • HLA-B27 blood test:
  • X-ray or MRI:

Treatment

Keep moving.

Self-care

  • Daily stretching and exercise
  • Good posture
  • Don't smoke

Medicines

Medicines that may help:

MedicineHelps withGood to know
NSAIDs
Pain
Biologics
Inflammation

OwieClear doesn't give doses: follow the label or your healthcare professional. Medicine names here are examples, not a full list.

Which doctor treats this

  • Start with your primary care provider (family doctor or internist).
  • They may send you to a rheumatologist (joint and immune system doctor).

Living with it

Support groups and helplines

Pregnancy and breastfeeding

  • If you're pregnant or planning to be, tell your prenatal provider about this condition.
  • Don't start or stop any medicine on your own. Some are safe in pregnancy and some need to be changed.
  • Ask before taking any pain reliever. The FDA advises avoiding ibuprofen and naproxen after 20 weeks unless your doctor says to.
  • Breastfeeding: Most medicines are fine, but ask. The NIH LactMed database lists what's known about each one.

Outlook

Treatment keeps most people active.

Getting ready for your visit

Bring a list of your symptoms and medicines.

What to bring

  • A list of your medicines and supplements
  • Notes on when symptoms started and what makes them better or worse

Questions to ask

  • Do I need a biologic?

Research studies

Research studies test new ways to find and treat health problems. Some are looking for volunteers. Talk with your doctor before joining one.

Search ClinicalTrials.gov for studies on Ankylosing spondylitis

Sources

Last updated 2026-11-12.