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Antibiotic-resistant infections (superbugs like MRSA, CRE, or ESBL)

Also called: Antibiotic-resistant infection, superbug, MRSA, CRE, ESBL

Some germs have learned to survive common germ-killing medicines. These infections need the right medicine and extra care to keep them from spreading.

ExamplesMRSA, CRE, ESBL, C. diff
PreventionHandwashing, using antibiotics only when needed

Overview

Taking antibiotics you don't need helps these germs grow stronger.

Most people who carry these germs on their skin are not sick.

Symptoms

Common signs:

  • Antibiotic-resistant infection

When to get medical care

Call 911Fever with confusion or low blood pressure.
Get care todaySpreading infection.
See a doctor soonInfection not improving.

Causes

Overuse of antibiotics.

Does it spread or run in families?

  • Yes, it can spread from person to person.
  • How it spreads: touch, hospitals, clinics, water, or usually your own gut bacteria.
  • Washing hands often and staying home when sick help protect others.

Who is more likely to get it

  • Hospital stays

Diagnosis

Cultures show which antibiotic works.

Tests

Tests, if needed:

  • Culture:

Treatment

Prevent spread.

Self-care

  • Wash hands
  • Cover wounds
  • Take antibiotics exactly as prescribed

Medicines

Medicines that may help:

MedicineHelps withGood to know
Specific antibiotics
Infection

OwieClear doesn't give doses: follow the label or your healthcare professional. Medicine names here are examples, not a full list.

Prevention

  • Handwashing

Which doctor treats this

  • Start with your primary care provider (family doctor or internist).
  • They may send you to an infectious disease specialist, for hard-to-treat infections.

Back to school, work, or sports

  • Stay home until 2 days after vomiting and diarrhea stop, especially if you work with food, children, or patients.
  • Wash hands well after using the toilet.

Pregnancy and breastfeeding

  • If you're pregnant or planning to be, tell your prenatal provider about this condition.
  • Some infections can pass to the baby during pregnancy or birth. Tell your provider if you've been exposed.
  • Don't start or stop any medicine on your own. Some are safe in pregnancy and some need to be changed.
  • Ask before taking any pain reliever. The FDA advises avoiding ibuprofen and naproxen after 20 weeks unless your doctor says to.
  • Breastfeeding: Most medicines are fine, but ask. The NIH LactMed database lists what's known about each one.

Outlook

Treatable.

Research studies

Research studies test new ways to find and treat health problems. Some are looking for volunteers. Talk with your doctor before joining one.

Search ClinicalTrials.gov for studies on Antibiotic-resistant infections (superbugs like MRSA, CRE, or ESBL)

Sources

Last updated 2026-11-12.