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Cluster headache

Also called: Horton's headache, histamine headache

Very severe headaches on one side of the head, with pain behind or around one eye. A watery eye or droopy eyelid on the same side is common. Attacks come in clusters, often at the same time each day, for weeks or months. Breathing pure oxygen can stop an attack.

TypeRare, very painful headache
WhereOne side, around one eye
Attack lengthStrongest pain 30 minutes to 2 hours
PatternDaily attacks for weeks, then pain-free
Common triggerAlcohol during a cluster period
TreatmentOxygen, triptan shots or nasal spray

Overview

A cluster headache is an uncommon type of headache. It causes severe pain on one side of the face, often around the eye, along with tearing, a red eye, a droopy eyelid, or a stuffy nose on the same side.

Attacks often strike 2 to 3 hours after falling asleep and tend to happen at the same time each day. They come in cluster periods that can last weeks to months, separated by pain-free periods of at least a month. Some people have chronic cluster headaches that go on for a year or more.

Symptoms

Pain starts suddenly and is often described as burning, sharp, or stabbing.

  • Headache on one side of the head, very severe
  • Pain behind or around one eye
  • Watery eye or droopy eyelid on the same side
  • Red eye or stuffy, runny nose on the same side
  • Restlessness or pacing during attacks

Less common

  • Swelling around the eye
  • Attacks several times a day

How it usually goes

  • 5 to 10 minutes: Pain reaches its worst.
  • 30 minutes to 2 hours: Strongest pain lasts this long.
  • Weeks to months: Daily attacks in a cluster period, then pain-free for at least a month.

When to get medical care

Call 911The worst headache of your life, a headache that starts suddenly, or headache with trouble speaking, seeing, moving, or keeping your balance. Headache with high fever and stiff neck.
Get care todayA first severe one-sided headache that has never been checked, or a headache with repeated vomiting.
See a doctor soonYour headache pattern changes, or treatments that once worked no longer help.

Causes

Doctors don't know exactly what causes cluster headaches. A part of the brain called the hypothalamus may play a part. Alcohol, smoking, high altitude, bright light, heat, exercise, nitrite foods, and some medicines can trigger attacks.

Does it spread or run in families?

  • It isn't contagious. You can't catch it from someone else.

Who is more likely to get it

  • Being male
  • Smoking
  • Alcohol during a cluster period

Diagnosis

A healthcare professional can usually diagnose it from your symptoms and an exam. Tests may be done to rule out other causes.

Questions you may be asked

  • Where the pain is and how bad it is
  • How long attacks last and what time they start
  • Eye or nose symptoms on the same side
  • Restlessness during attacks
  • Alcohol and smoking

The exam

They'll check your eyes, nerves, and reflexes. During an attack, the eyelid may droop and the pupil may look small.

Tests

Tests may include:

  • Brain MRI or CT scan: To rule out other causes of headache.

Treatment

Treatment doesn't cure cluster headaches but can stop attacks and help prevent them.

Self-care

  • Avoid alcohol during a cluster period
  • Don't smoke
  • Keep a headache diary of when attacks start, how long they last, and what stops them
  • Keep a regular sleep schedule
  • Avoid other triggers, like heat, bright light, and nitrite foods (bacon, preserved meats)

Medicines

Cluster headache treatment needs a prescription.

MedicineHelps withGood to know
Oxygen
Stops many attacks quickly, with few side effectsNeeds a prescription and equipment. Keep away from flames and smoking.
Triptans
Stops an attack fastNot for people with some heart or blood vessel problems. Limits on how often you can use them.
Preventive medicines
Fewer attacks during a cluster periodYour doctor will taper them off when the cluster ends.

Over-the-counter pain relievers usually don't help because the pain peaks before they work.

Regular pain pills usually don't work because they act too slowly. Your doctor may prescribe oxygen to use at home, fast-acting triptans, and medicine to prevent attacks during a cluster period. A nerve stimulator is an option if nothing else works.

How it compares

Cluster headacheMigraineTension headacheTrigeminal neuralgia
PainVery severe, around one eyeThrobbing, often one sideTight band, both sidesElectric shocks in the face
Eye and noseTearing, droopy lid, stuffy noseLight sensitivityNoneNone

Prevention

You may lower the number of attacks:

  • Avoid alcohol during cluster periods
  • Don't smoke
  • Keep regular sleep times
  • Take preventive medicine if prescribed

Which doctor treats this

  • Start with your primary care provider (family doctor or internist).
  • They may send you to a neurologist (brain and nerve doctor).

Living with it

  • Keep a simple diary of symptoms, triggers, and medicines to bring to visits.
  • Bring a list of your medicines and questions to each visit.
  • Stay active in ways that feel good to you.
  • Get enough sleep and manage stress.
  • Long-term illness can affect mood. Tell your doctor if you feel down or anxious.

Back to school, work, or sports

  • Most people can keep working or going to school.
  • Ask about changes that help, like extra breaks or a flexible schedule. Workers may be covered by the ADA. Students may get a 504 plan.

Children, pregnancy, and older adults

  • Pregnancy: Oxygen may be an option. Talk with your doctor about safe treatments.
  • Older adults: Triptans may not be safe with heart problems; oxygen may be an option.

Pregnancy and breastfeeding

  • If you're pregnant or planning to be, tell your prenatal provider about this condition.
  • Don't start or stop any medicine on your own. Some are safe in pregnancy and some need to be changed.
  • Ask before taking any pain reliever. The FDA advises avoiding ibuprofen and naproxen after 20 weeks unless your doctor says to.
  • Breastfeeding: Most medicines are fine, but ask. The NIH LactMed database lists what's known about each one.

For caregivers

  • Go to visits when you can and take notes.
  • Keep a list of medicines, allergies, and doctors in one place.
  • Learn the warning signs that need fast care.
  • Take breaks and ask for help. Caregivers need care too.

Outlook

Cluster headaches can come and go for years. Treatment can stop attacks and make cluster periods easier.

Getting ready for your visit

A headache diary is very helpful.

What to bring

  • Dates, times, and length of attacks
  • Eye and nose symptoms
  • Alcohol, smoking, and other triggers
  • Medicines you've tried

Questions to ask

  • Is this a cluster headache?
  • Can I get oxygen at home?
  • Which medicine should I use during an attack?
  • How can I prevent attacks?

Research studies

Research studies test new ways to find and treat health problems. Some are looking for volunteers. Talk with your doctor before joining one.

Search ClinicalTrials.gov for studies on Cluster headache

Sources

Last updated 2026-11-12.