Overview
CRPS often follows a fracture, sprain, or surgery, with pain far greater than expected.
Skin may change color, temperature, or texture.
Symptoms
Common signs:
- Severe pain after injury
- Burning pain, swelling, and color change in a limb after an injury
Less common
- Swelling
- Color changes
- Stiffness
- Hair or nail changes
When to get medical care
Causes
Nerve dysfunction.
Does it spread or run in families?
- It isn't contagious. You can't catch it from someone else.
Diagnosis
Diagnosis by exam.
Treatment
Keep moving.
Self-care
- Physical therapy
- Use the limb gently
- Try mirror therapy
Medicines
Medicines that may help:
| Medicine | Helps with | Good to know |
|---|---|---|
| Pain relievers | Pain and swelling | Ask first if you have kidney, stomach, or heart problems. |
OwieClear doesn't give doses: follow the label or your healthcare professional. Medicine names here are examples, not a full list.
Which doctor treats this
- Start with your primary care provider (family doctor or internist).
- They may send you to a neurologist (brain and nerve doctor).
Living with it
Support groups and helplines
- Genetic and Rare Diseases Information Center (GARD): Free NIH information on rare diseases, including where to find experts and patient groups.
- National Organization for Rare Disorders (NORD): Patient groups, help finding care, and aid programs for rare diseases.
Children, pregnancy, and older adults
- Women: More common.
Pregnancy and breastfeeding
- If you're pregnant or planning to be, tell your prenatal provider about this condition.
- Don't start or stop any medicine on your own. Some are safe in pregnancy and some need to be changed.
- Ask before taking any pain reliever. The FDA advises avoiding ibuprofen and naproxen after 20 weeks unless your doctor says to.
- Breastfeeding: Most medicines are fine, but ask. The NIH LactMed database lists what's known about each one.
Outlook
Early treatment helps.
Getting ready for your visit
Bring a list of your symptoms and medicines.
What to bring
- A list of your medicines and supplements
- Notes on when symptoms started and what makes them better or worse
Questions to ask
- Would a nerve block help?
Research studies
Research studies test new ways to find and treat health problems. Some are looking for volunteers. Talk with your doctor before joining one.
Search ClinicalTrials.gov for studies on Complex regional pain syndrome (CRPS)
Sources
Last updated 2026-11-12.