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Early menopause (primary ovarian insufficiency)

Also called: Primary ovarian insufficiency, early menopause, POI

The ovaries stop working normally before age 40, causing missed periods and menopause symptoms. Hormone therapy protects bones and heart.

BeforeAge 40
TreatmentHormone therapy until about 50

Overview

Some people still ovulate now and then.

Symptoms

Common signs:

  • Missed periods before 40
  • Missed or late period
  • Hot flashes or night sweats

Less common

  • Hot flashes
  • Trouble getting pregnant

When to get medical care

Call 911This isn't an emergency by itself. Call 911 for trouble breathing, chest pain, or fainting.
Get care todayNew or worse symptoms, or symptoms with fever.
See a doctor soonSymptoms that last or keep coming back.

Causes

Genes, immune, treatments.

Does it spread or run in families?

  • It isn't contagious. You can't catch it from someone else.
  • It can run in families. Tell your doctor if a parent, brother, or sister has it.

Who is more likely to get it

  • Chemo
  • Family history

Diagnosis

A clinician asks about your symptoms and may order tests.

The exam

A physical exam.

Tests

Tests, if needed:

  • Hormone tests:

Treatment

Treatment depends on the cause and how severe it is.

Self-care

  • Calcium and vitamin D
  • Weight-bearing exercise

Which doctor treats this

  • Start with your primary care provider (family doctor or internist).
  • They may send you to a gynecologist (OB-GYN).

Living with it

  • Keep a simple diary of symptoms, triggers, and medicines to bring to visits.
  • Bring a list of your medicines and questions to each visit.
  • Stay active in ways that feel good to you.
  • Get enough sleep and manage stress.
  • Long-term illness can affect mood. Tell your doctor if you feel down or anxious.

Back to school, work, or sports

  • Most people can keep working or going to school.
  • Ask about changes that help, like extra breaks or a flexible schedule. Workers may be covered by the ADA. Students may get a 504 plan.

Pregnancy and breastfeeding

  • If you're pregnant or planning to be, tell your prenatal provider about this condition.
  • Don't start or stop any medicine on your own. Some are safe in pregnancy and some need to be changed.
  • Ask before taking any pain reliever. The FDA advises avoiding ibuprofen and naproxen after 20 weeks unless your doctor says to.
  • Breastfeeding: Most medicines are fine, but ask. The NIH LactMed database lists what's known about each one.

For caregivers

  • Go to visits when you can and take notes.
  • Keep a list of medicines, allergies, and doctors in one place.
  • Learn the warning signs that need fast care.
  • Take breaks and ask for help. Caregivers need care too.

Outlook

Outlook depends on the cause; early care helps.

Getting ready for your visit

Bring a list of your symptoms and medicines.

What to bring

  • A list of your medicines and supplements
  • Notes on when symptoms started and what makes them better or worse

Questions to ask

  • What's causing this?
  • What treatment do you recommend?

Research studies

Research studies test new ways to find and treat health problems. Some are looking for volunteers. Talk with your doctor before joining one.

Search ClinicalTrials.gov for studies on Early menopause (primary ovarian insufficiency)

Sources

Last updated 2026-11-12.