Overview
Some medicines and supplements can harm the liver.
Symptoms
Common signs:
- Enlarged liver found
Less common
- Upper right belly fullness
- Tiredness
When to get medical care
Call 911Vomiting blood or confusion.
Get care todayYellow skin or eyes, or a swollen belly.
See a doctor soonEnlarged liver found.
Causes
Fatty liver, alcohol, infection, heart failure.
Does it spread or run in families?
- It isn't contagious. You can't catch it from someone else.
Who is more likely to get it
- Heavy drinking
- Obesity
Possible complications
Diagnosis
Tests find the cause.
Questions you may be asked
- Alcohol, medicines, supplements
The exam
Belly exam.
Tests
Tests, if needed:
- Liver tests:
- Hepatitis tests:
- Ultrasound:
Treatment
Protect your liver.
Self-care
- Limit or stop alcohol
- Check supplements with your doctor
- Get hepatitis vaccines
- Keep a healthy weight
Prevention
- Limit alcohol
Which doctor treats this
- Start with your primary care provider (family doctor or internist).
- They may send you to a gastroenterologist or hepatologist (liver doctor).
Living with it
Support groups and helplines
- American Liver Foundation: Helpline and support groups for liver disease.
Pregnancy and breastfeeding
- If you're pregnant or planning to be, tell your prenatal provider about this condition.
- Don't start or stop any medicine on your own. Some are safe in pregnancy and some need to be changed.
- Ask before taking any pain reliever. The FDA advises avoiding ibuprofen and naproxen after 20 weeks unless your doctor says to.
- Breastfeeding: Most medicines are fine, but ask. The NIH LactMed database lists what's known about each one.
Outlook
Depends on cause.
Research studies
Research studies test new ways to find and treat health problems. Some are looking for volunteers. Talk with your doctor before joining one.
Search ClinicalTrials.gov for studies on Enlarged liver (hepatomegaly)
Sources
Last updated 2026-11-12.