Overview
An enlarged spleen can be from mono, liver disease, or blood conditions.
A big spleen can rupture with a hit, so contact sports are avoided.
Symptoms
Common signs:
- Fullness under left ribs
- Upper left belly pain (under the left ribs)
Less common
- Feeling full fast
- Low blood counts
When to get medical care
Causes
Infections, liver, blood.
Does it spread or run in families?
- It isn't contagious. You can't catch it from someone else.
Diagnosis
A clinician asks about your symptoms and may order tests.
The exam
A physical exam.
Tests
Tests, if needed:
- Ultrasound:
Treatment
Treatment depends on the cause and how severe it is.
Self-care
- Avoid contact sports
Prevention
To lower your risk or prevent problems:
- Treat the cause
Which doctor treats this
- Start with your primary care provider (family doctor or internist).
- They may send you to a hematologist (blood doctor).
Children, pregnancy, and older adults
- Teens with mono: Avoid contact sports for at least 4 weeks.
- People with mono: Avoid sports for weeks.
Pregnancy and breastfeeding
- If you're pregnant or planning to be, tell your prenatal provider about this condition.
- Don't start or stop any medicine on your own. Some are safe in pregnancy and some need to be changed.
- Ask before taking any pain reliever. The FDA advises avoiding ibuprofen and naproxen after 20 weeks unless your doctor says to.
- Breastfeeding: Most medicines are fine, but ask. The NIH LactMed database lists what's known about each one.
Outlook
Outlook depends on the cause; early care helps.
Getting ready for your visit
Bring a list of your symptoms and medicines.
What to bring
- A list of your medicines and supplements
- Notes on when symptoms started and what makes them better or worse
Questions to ask
- What's causing this?
- What treatment do you recommend?
- What's causing it?
Research studies
Research studies test new ways to find and treat health problems. Some are looking for volunteers. Talk with your doctor before joining one.
Search ClinicalTrials.gov for studies on Enlarged spleen (splenomegaly)
Sources
Last updated 2026-11-12.