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Fifth disease (slapped cheek)

Also called: Fifth disease, slapped cheek syndrome, parvovirus B19, erythema infectiosum

A mild viral illness, mostly in children, that causes bright red cheeks and then a lacy, pink rash on the arms and legs. Adults may get joint pain instead.

CauseParvovirus B19
ContagiousBefore the rash; not once it appears
WatchPregnancy and sickle cell

Overview

It starts like a cold with a low fever. The rash can come and go for weeks, especially with heat.

Infection in pregnancy can rarely harm the baby, and it can cause severe anemia in people with sickle cell disease.

Symptoms

Common signs:

  • Bright red cheeks
  • Lacy rash
  • Bright red cheeks like a slap

Less common

  • Low fever
  • Joint pain in adults

When to get medical care

Call 911A pale, very tired, or short-of-breath person with sickle cell disease.
Get care todayExposure during pregnancy.
See a doctor soonJoint pain lasting weeks.

Causes

Parvovirus B19.

Does it spread or run in families?

  • Yes, it can spread from person to person.
  • How it spreads: coughs or sneezes; can pass to an unborn baby.
  • Washing hands often and staying home when sick help protect others.

Who is more likely to get it

  • Children 5 to 15

Diagnosis

Diagnosis is based on the rash.

Questions you may be asked

  • Pregnancy or blood disorders in the home

Tests

Tests, if needed:

  • Blood test: In pregnancy.

Treatment

Comfort care.

Self-care

  • Rest and fluids
  • Use fever or pain medicine
  • Children can go to school once the rash shows

Medicines

Medicines that may help:

MedicineHelps withGood to know
Pain and fever relievers
Fever and joint pain

OwieClear doesn't give doses: follow the label or your healthcare professional. Medicine names here are examples, not a full list.

Prevention

To prevent spread:

  • Handwashing

Which doctor treats this

  • Start with your child's pediatrician.

Back to school, work, or sports

  • You usually don't need to miss school or work. Wash hands often.

Pregnancy and breastfeeding

  • If you're pregnant or planning to be, tell your prenatal provider about this condition.
  • Some infections can pass to the baby during pregnancy or birth. Tell your provider if you've been exposed.
  • Don't start or stop any medicine on your own. Some are safe in pregnancy and some need to be changed.
  • Ask before taking any pain reliever. The FDA advises avoiding ibuprofen and naproxen after 20 weeks unless your doctor says to.
  • Breastfeeding: Most medicines are fine, but ask. The NIH LactMed database lists what's known about each one.

For caregivers

  • Learn the warning signs and when to call the doctor or 911.
  • Keep a list of your child's medicines, doses, and doctors on your phone.
  • Tell teachers, coaches, and sitters what to watch for and what to do.
  • Take breaks and ask for help. Caregivers need care too.

Outlook

Clears on its own.

Research studies

Research studies test new ways to find and treat health problems. Some are looking for volunteers. Talk with your doctor before joining one.

Search ClinicalTrials.gov for studies on Fifth disease (slapped cheek)

Sources

Last updated 2026-11-12.