Overview
Severe skin reactions with blisters are rare but serious.
Symptoms
Common signs:
- Rash or hives after a medicine
- Rash or reaction after starting a medicine
Less common
- Itching
- Swelling
Look up a symptom: Hives or welts · Itching · Rash · Rash or reaction after starting a medicine
When to get medical care
Causes
Immune reaction or side effect.
Does it spread or run in families?
- It isn't contagious. You can't catch it from someone else.
Possible complications
Diagnosis
A clinician reviews the reaction.
Questions you may be asked
- Which medicine, timing
Tests
Tests, if needed:
- Allergy testing:
Treatment
Stop and call.
Self-care
- Call your prescriber
- Keep a list of reactions
Medicines
Medicines that may help:
| Medicine | Helps with | Good to know |
|---|---|---|
| Antihistamines | Mild rash |
OwieClear doesn't give doses: follow the label or your healthcare professional. Medicine names here are examples, not a full list.
Which doctor treats this
- Start with your primary care provider (family doctor or internist).
- They may send you to an allergist (allergy and asthma doctor).
Living with it
Support groups and helplines
- Asthma and Allergy Foundation of America: Education and online support for asthma, allergies, and eczema.
Pregnancy and breastfeeding
- If you're pregnant or planning to be, tell your prenatal provider about this condition.
- Don't start or stop any medicine on your own. Some are safe in pregnancy and some need to be changed.
- Ask before taking any pain reliever. The FDA advises avoiding ibuprofen and naproxen after 20 weeks unless your doctor says to.
- Breastfeeding: Most medicines are fine, but ask. The NIH LactMed database lists what's known about each one.
Outlook
Usually resolves.
Research studies
Research studies test new ways to find and treat health problems. Some are looking for volunteers. Talk with your doctor before joining one.
Search ClinicalTrials.gov for studies on Medicine allergy or side effect
Sources
Last updated 2026-11-12.