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Muscle breakdown (rhabdomyolysis)

Also called: Rhabdomyolysis, muscle breakdown

Damaged muscle releases proteins that can harm the kidneys. Signs are severe muscle pain, weakness, and dark, cola-colored urine.

CausesExtreme exercise, heat, crush injuries, some medicines

Overview

It can follow a hard new workout, especially in heat.

Symptoms

Common signs:

  • Dark, cola-colored urine
  • Severe muscle pain
  • Weakness

Less common

  • Little urine

When to get medical care

Call 911Call 911 now for: dark, cola-colored urine, severe muscle pain, weakness.
Get care todayMilder symptoms that could be early signs.
See a doctor soonQuestions about lowering your risk.

Causes

Muscle damage.

Does it spread or run in families?

  • It isn't contagious. You can't catch it from someone else.

Who is more likely to get it

  • Extreme exercise
  • Heat
  • Statins with other drugs

Diagnosis

This is diagnosed in the emergency room or hospital.

The exam

A physical exam.

Tests

Tests, if needed:

  • CK blood test:
  • Urine test:

Treatment

Emergency care is needed. While waiting for help:

Self-care

  • Drink fluids
  • Go to the ER

Prevention

To lower your risk or catch problems early:

  • Build up exercise slowly
  • Hydrate in heat

Which doctor treats this

  • Emergency doctors treat it first, in the ER.
  • They may send you to a physical therapist, or a sports medicine doctor.
  • A physical therapist can help with exercises to rebuild strength and motion.

Back to school, work, or sports

  • Recovery time varies. Ask your care team when you can drive, lift, work, and exercise.

Pregnancy and breastfeeding

  • If you're pregnant or planning to be, tell your prenatal provider about this condition.
  • Don't start or stop any medicine on your own. Some are safe in pregnancy and some need to be changed.
  • Ask before taking any pain reliever. The FDA advises avoiding ibuprofen and naproxen after 20 weeks unless your doctor says to.
  • Breastfeeding: Most medicines are fine, but ask. The NIH LactMed database lists what's known about each one.

For caregivers

  • Go to visits when you can and take notes.
  • Keep a list of medicines, allergies, and doctors in one place.
  • Learn the warning signs that need fast care.
  • Learn CPR. Many hospitals and the Red Cross offer classes.
  • Take breaks and ask for help. Caregivers need care too.

Outlook

IV fluids protect the kidneys.

Getting ready for your visit

Bring a list of your symptoms and medicines.

What to bring

  • A list of your medicines and supplements
  • Notes on when symptoms started and what makes them better or worse

Questions to ask

  • What follow-up care do I need?
  • How can I prevent this from happening again?

Research studies

Research studies test new ways to find and treat health problems. Some are looking for volunteers. Talk with your doctor before joining one.

Search ClinicalTrials.gov for studies on Muscle breakdown (rhabdomyolysis)

Sources

Last updated 2026-11-12.