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Opioid use and dependence

Also called: Opioid use disorder, opioid dependence, opioid addiction, fentanyl

Trouble controlling use of opioids like pain pills, heroin, or fentanyl. It's a treatable medical condition, and medicines like buprenorphine and methadone save lives.

OverdoseCall 911, give naloxone (Narcan)
TreatmentBuprenorphine, methadone, naltrexone
Help lineSAMHSA 1-800-662-4357

Overview

Withdrawal causes aches, sweating, diarrhea, and cravings but usually isn't deadly.

Street drugs are often laced with fentanyl; test strips and naloxone save lives.

Symptoms

Common signs:

  • Trouble controlling opioid use
  • Pinpoint pupils, nodding off, or constipation from opioids

Less common

  • Withdrawal symptoms
  • Cravings

When to get medical care

Call 911Not waking, slow or no breathing, blue lips: call 911 and give naloxone.
Get care todayThoughts of suicide or harming yourself or others: call or text 988, or call 911.
See a doctor soonYou want help.

Causes

Opioids change the brain.

Does it spread or run in families?

  • It isn't contagious. You can't catch it from someone else.
  • It can run in families. Tell your doctor if a parent, brother, or sister has it.

Who is more likely to get it

  • Chronic pain
  • Family history

Possible complications

  • Opioid overdose

Diagnosis

A clinician talks with you.

Questions you may be asked

  • Use, past treatment

Treatment

Start treatment.

Self-care

  • Ask a doctor about buprenorphine
  • Keep naloxone at home
  • Never use alone

Medicines

Medicines that may help:

MedicineHelps withGood to know
Buprenorphine
CravingsPrescription.
Methadone
CravingsClinic.
Naloxone
OverdoseNo prescription needed.

OwieClear doesn't give doses: follow the label or your healthcare professional. Medicine names here are examples, not a full list.

Which doctor treats this

  • Start with your primary care provider (family doctor or internist).
  • They may send you to an addiction medicine doctor or a licensed counselor.

Living with it

  • Keep a regular sleep, meal, and activity routine.
  • Tell one trusted person how you're doing, and plan who to call on hard days.
  • Limit alcohol and drugs. They often make symptoms worse.
  • In a crisis, call or text 988 any time.
  • Long-term illness can affect mood. Tell your doctor if you feel down or anxious.

Support groups and helplines

Back to school, work, or sports

  • Most people can keep working or going to school.
  • Ask about changes that help, like extra breaks or a flexible schedule. Workers may be covered by the ADA. Students may get a 504 plan.
  • The Family and Medical Leave Act (FMLA) may let you take unpaid time off for treatment without losing your job.

Pregnancy and breastfeeding

  • If you're pregnant or planning to be, tell your prenatal provider about this condition.
  • Many mental health medicines are used safely in pregnancy. Stopping suddenly can cause a relapse.
  • Don't start or stop any medicine on your own. Some are safe in pregnancy and some need to be changed.
  • Ask before taking any pain reliever. The FDA advises avoiding ibuprofen and naproxen after 20 weeks unless your doctor says to.
  • Mood problems can start during or after pregnancy. Postpartum Support International: 1-800-944-4773.
  • Breastfeeding: Most medicines are fine, but ask. The NIH LactMed database lists what's known about each one.

For caregivers

  • Listen without judging, and let them know you care.
  • Encourage treatment, but don't force it unless they're in danger.
  • If they talk about suicide, call or text 988 with them.
  • Take breaks and ask for help. Caregivers need care too.

Outlook

Treatment works.

Research studies

Research studies test new ways to find and treat health problems. Some are looking for volunteers. Talk with your doctor before joining one.

Search ClinicalTrials.gov for studies on Opioid use and dependence

Sources

Last updated 2026-11-12.