Overview
Pemphigoid blisters are tense and itchy; pemphigus blisters break easily and often start in the mouth.
Symptoms
Common signs:
- Blisters on skin or in the mouth
Less common
- Itching
- Raw areas
When to get medical care
Call 911Widespread blisters with fever.
Get care todayNew blisters.
See a doctor soonSymptoms that last or keep coming back.
Causes
Immune.
Who is more likely to get it
- Older adults
Diagnosis
A clinician asks about your symptoms and may order tests.
The exam
A physical exam.
Tests
Tests, if needed:
- Skin biopsy:
Treatment
Treatment depends on the cause and how severe it is.
Self-care
- Gentle skin care
- Cover open areas
- Protect blisters with clean, non-stick bandages
- Use gentle soap
Which doctor treats this
- Urgent care or the ER can treat it first. For minor problems, your primary care provider can help.
- They may send you to a dermatologist (skin doctor).
Living with it
Support groups and helplines
- Genetic and Rare Diseases Information Center (GARD): Free NIH information on rare diseases, including where to find experts and patient groups.
- National Organization for Rare Disorders (NORD): Patient groups, help finding care, and aid programs for rare diseases.
Back to school, work, or sports
- Most people can go to school or work. Keep the wound clean and covered.
- Avoid pools and hot tubs until the skin heals.
Children, pregnancy, and older adults
- Older adults: Pemphigoid is most common.
- Adults 40 to 60: Pemphigus most common.
Outlook
Treatment controls most cases.
Medicines control most cases.
Getting ready for your visit
Bring a list of your symptoms and medicines.
What to bring
- A list of your medicines and supplements
- Notes on when symptoms started and what makes them better or worse
Questions to ask
- What's causing this?
- What treatment do you recommend?
Research studies
Research studies test new ways to find and treat health problems. Some are looking for volunteers. Talk with your doctor before joining one.
Search ClinicalTrials.gov for studies on Pemphigus and pemphigoid (blistering skin diseases)
Sources
Last updated 2026-11-12.