Overview
OHSS happens when fertility medicines make the ovaries swell and leak fluid into the belly.
Most cases are mild and go away in 1 to 2 weeks.
Symptoms
Common signs:
- Severe belly swelling
- Shortness of breath
- Peeing very little
- Bloating or gas
- Pelvic or lower belly pain
Less common
- Nausea
- Weight gain
When to get medical care
Causes
Fertility medicines.
Does it spread or run in families?
- It isn't contagious. You can't catch it from someone else.
Who is more likely to get it
- IVF
Possible complications
- Blood clot in the leg (DVT): Thick blood raises clot risk
- Twisted ovary (ovarian torsion): A swollen ovary can twist
Diagnosis
This is diagnosed in the emergency room or hospital.
The exam
A physical exam.
Tests
Tests, if needed:
- Ultrasound:
Treatment
Emergency care is needed. While waiting for help:
Self-care
- Call your fertility clinic or 911
Prevention
To lower your risk or prevent problems:
- Close monitoring during fertility treatment
Which doctor treats this
- Start with your primary care provider (family doctor or internist).
- They may send you to an OB-GYN or midwife; high-risk pregnancies may see a maternal-fetal medicine doctor.
Living with it
- Keep a simple diary of symptoms, triggers, and medicines to bring to visits.
- Bring a list of your medicines and questions to each visit.
- Stay active in ways that feel good to you.
- Get enough sleep and manage stress.
- Long-term illness can affect mood. Tell your doctor if you feel down or anxious.
Back to school, work, or sports
- Most people can keep working or going to school.
- Ask about changes that help, like extra breaks or a flexible schedule. Workers may be covered by the ADA. Students may get a 504 plan.
Children, pregnancy, and older adults
- People with PCOS: Higher risk.
For caregivers
- Go to visits when you can and take notes.
- Keep a list of medicines, allergies, and doctors in one place.
- Learn the warning signs that need fast care.
- Take breaks and ask for help. Caregivers need care too.
Outlook
Most mild cases go away.
Getting ready for your visit
Bring a list of your symptoms and medicines.
What to bring
- A list of your medicines and supplements
- Notes on when symptoms started and what makes them better or worse
Questions to ask
- What follow-up care do I need?
- How can I prevent this from happening again?
Research studies
Research studies test new ways to find and treat health problems. Some are looking for volunteers. Talk with your doctor before joining one.
Search ClinicalTrials.gov for studies on Problems after fertility treatment (OHSS)
Sources
Last updated 2026-11-12.