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Smallpox and related poxviruses

Also called: Smallpox, mpox-related poxviruses

Smallpox was eliminated worldwide in 1980. Related poxviruses can still cause rashes and need public health care.

SmallpoxEradicated

Overview

Smallpox has been eradicated. Mpox and other poxviruses still cause outbreaks.

Public health teams handle any suspected case.

Symptoms

Common signs:

  • Fever with a blistering rash
  • Pimple-like bumps that turn into blisters or scabs

Less common

  • Body aches

When to get medical care

Call 911Call 911 now for: fever with a blistering rash.
Get care todayMilder symptoms that could be early signs.
See a doctor soonQuestions about lowering your risk.

Causes

Poxviruses.

Does it spread or run in families?

  • The illness itself usually isn't passed to others, but some germs that cause it can spread.
  • Washing hands often helps.

Diagnosis

This is diagnosed in the emergency room or hospital.

The exam

A physical exam.

Tests

Tests, if needed:

  • Tests:

Treatment

Emergency care is needed. While waiting for help:

Self-care

  • Isolate and call ahead
  • Stay isolated

Prevention

To lower your risk or prevent problems:

  • Vaccines for some at-risk groups

Which doctor treats this

  • Emergency doctors treat it first, in the ER.
  • They may send you to an infectious disease specialist, for hard-to-treat infections.

Back to school, work, or sports

  • Recovery time varies. Ask your care team when you can drive, lift, work, and exercise.

Children, pregnancy, and older adults

  • Lab workers: Higher risk.

Pregnancy and breastfeeding

  • If you're pregnant or planning to be, tell your prenatal provider about this condition.
  • Some infections can pass to the baby during pregnancy or birth. Tell your provider if you've been exposed.
  • Don't start or stop any medicine on your own. Some are safe in pregnancy and some need to be changed.
  • Ask before taking any pain reliever. The FDA advises avoiding ibuprofen and naproxen after 20 weeks unless your doctor says to.
  • Breastfeeding: Most medicines are fine, but ask. The NIH LactMed database lists what's known about each one.

For caregivers

  • Go to visits when you can and take notes.
  • Keep a list of medicines, allergies, and doctors in one place.
  • Learn the warning signs that need fast care.
  • Learn CPR. Many hospitals and the Red Cross offer classes.
  • Take breaks and ask for help. Caregivers need care too.

Outlook

Public health care contains outbreaks.

Smallpox was wiped out; mpox is treatable.

Getting ready for your visit

Bring a list of your symptoms and medicines.

What to bring

  • A list of your medicines and supplements
  • Notes on when symptoms started and what makes them better or worse

Questions to ask

  • What follow-up care do I need?
  • How can I prevent this from happening again?

Research studies

Research studies test new ways to find and treat health problems. Some are looking for volunteers. Talk with your doctor before joining one.

Search ClinicalTrials.gov for studies on Smallpox and related poxviruses

Sources

Last updated 2026-11-12.