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Triple X syndrome (47,XXX)

Also called: Triple X syndrome, trisomy X, 47,XXX

Girls and women born with an extra X chromosome. Many never know. Some are taller and have learning, speech, or attention differences that respond well to early support.

How commonAbout 1 in 1,000 girls
Found byGenetic test, often by chance
HelpEarly speech and learning support

Overview

Fertility is usually normal, though some have early menopause.

It isn't inherited from parents in most cases.

Symptoms

Common signs:

  • Triple X diagnosis

Less common

  • Learning or speech delays
  • Tall height
  • Low muscle tone

When to get medical care

Call 911This isn't an emergency by itself. Call 911 for trouble breathing, chest pain, or fainting.
Get care todaySeizures, a fall in skills, or big behavior changes.
See a doctor soonLearning, speech, or mood concerns.

Causes

An extra X from a random cell division.

Does it spread or run in families?

  • It isn't contagious. You can't catch it from someone else.

Diagnosis

A genetic test confirms it.

Tests

Tests, if needed:

  • Chromosome test (karyotype):

Treatment

Early support helps.

Self-care

  • Early intervention for speech or motor delays
  • School evaluation if learning is hard
  • Keep up with school support
  • Encourage activities she enjoys

Prevention

It can't be prevented.

  • There is no known way to prevent it. Early checkups help find it sooner.

Which doctor treats this

  • Start with your primary care provider (family doctor or internist).
  • They may send you to a medical geneticist (genetics doctor).

Children, pregnancy, and older adults

  • Adults: Some have early menopause; ask about fertility planning.

Pregnancy and breastfeeding

  • If you're pregnant or planning to be, tell your prenatal provider about this condition.
  • Don't start or stop any medicine on your own. Some are safe in pregnancy and some need to be changed.
  • Ask before taking any pain reliever. The FDA advises avoiding ibuprofen and naproxen after 20 weeks unless your doctor says to.
  • Breastfeeding: Most medicines are fine, but ask. The NIH LactMed database lists what's known about each one.

Outlook

Most live healthy, full lives.

Getting ready for your visit

Bring a list of your symptoms and medicines.

Questions to ask

  • Which checkups do we need?
  • Should we check her heart or kidneys?

Research studies

Research studies test new ways to find and treat health problems. Some are looking for volunteers. Talk with your doctor before joining one.

Search ClinicalTrials.gov for studies on Triple X syndrome (47,XXX)

Sources

Last updated 2026-11-12.