Overview
Some eye drops and allergy patches can enlarge one pupil.
Symptoms
Common signs:
- Pupils different sizes
Less common
- Droopy eyelid
- Blurry vision
- Light sensitivity
- Headache
When to get medical care
Call 911New unequal pupils after a head injury, with severe headache, or Sudden face drooping, arm weakness, trouble speaking, or vision loss: call 911.
Get care todayNew unequal pupils.
See a doctor soonA difference you've just noticed.
Causes
Normal, drops, nerve problems.
Does it spread or run in families?
- It isn't contagious. You can't catch it from someone else.
Diagnosis
An eye exam checks how pupils react.
Questions you may be asked
- Eye drops, injuries
Treatment
Get checked if new.
Self-care
- Note when you first noticed
- Look at old photos to see if the difference was always there
- Note any eye drops, patches, or plants you touched
Prevention
To lower your risk or prevent problems:
- Wash hands after using eye drops or patches
Which doctor treats this
- Start with your primary care provider (family doctor or internist).
- They may send you to an optometrist or ophthalmologist (eye doctor).
Children, pregnancy, and older adults
- Children: Often normal, but check if new.
Pregnancy and breastfeeding
- If you're pregnant or planning to be, tell your prenatal provider about this condition.
- Don't start or stop any medicine on your own. Some are safe in pregnancy and some need to be changed.
- Ask before taking any pain reliever. The FDA advises avoiding ibuprofen and naproxen after 20 weeks unless your doctor says to.
- Breastfeeding: Most medicines are fine, but ask. The NIH LactMed database lists what's known about each one.
Outlook
Often normal.
New causes are treatable when found early.
Getting ready for your visit
Bring a list of your symptoms and medicines.
Questions to ask
- Is this difference normal for me?
Research studies
Research studies test new ways to find and treat health problems. Some are looking for volunteers. Talk with your doctor before joining one.
Search ClinicalTrials.gov for studies on Unequal pupils (anisocoria)
Sources
Last updated 2026-11-12.