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XYY syndrome (47,XYY)

Also called: XYY syndrome, Jacobs syndrome, 47,XYY

Boys and men born with an extra Y chromosome. Many never know. Some are taller and have learning, speech, or attention differences that respond well to support.

How commonAbout 1 in 1,000 boys
Found byGenetic test, often by chance
HelpEarly support

Overview

Fertility is usually normal.

Older ideas that it causes aggression are not true.

Symptoms

Common signs:

  • XYY diagnosis

Less common

  • Learning or speech delays
  • Tall height
  • Low muscle tone

When to get medical care

Call 911This isn't an emergency by itself. Call 911 for trouble breathing, chest pain, or fainting.
Get care todaySeizures, a fall in skills, or big behavior changes.
See a doctor soonLearning or attention concerns.

Causes

An extra Y from a random cell division.

Does it spread or run in families?

  • It isn't contagious. You can't catch it from someone else.

Diagnosis

A genetic test confirms it.

Tests

Tests, if needed:

  • Chromosome test (karyotype):

Treatment

Early support helps.

Self-care

  • Early intervention
  • School evaluation
  • Keep regular checkups
  • Encourage sports and activities he enjoys

Prevention

It can't be prevented.

  • There is no known way to prevent it. Early checkups help find it sooner.

Which doctor treats this

  • Start with your primary care provider (family doctor or internist).
  • They may send you to a medical geneticist (genetics doctor).

Children, pregnancy, and older adults

  • Teens: Some may need help with attention or social skills.

Outlook

Most live healthy, full lives.

Life expectancy is normal.

Getting ready for your visit

Bring a list of your symptoms and medicines.

Questions to ask

  • Should we tell school?

Research studies

Research studies test new ways to find and treat health problems. Some are looking for volunteers. Talk with your doctor before joining one.

Search ClinicalTrials.gov for studies on XYY syndrome (47,XYY)

Sources

Last updated 2026-11-12.