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Amoxicillin and clavulanate

Brand names: Augmentin

Amoxicillin-clavulanate (Augmentin) is a penicillin antibiotic that works against more kinds of bacteria than amoxicillin alone.

Brand namesAugmentin
Type of medicinePenicillin antibiotic
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

Clavulanate blocks an enzyme some bacteria use to resist amoxicillin.

It doesn't work on colds, flu, or other viruses.

What it's used for

  • Sinus and ear infections
  • Some pneumonias
  • Skin infections and animal bites
  • Urinary tract infections

How to take it

  • Take it at the start of a meal to lower stomach upset.
  • Finish the full course even if you feel better.
  • Different strengths aren't interchangeable; use only what's prescribed.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Diarrhea
  • Nausea
  • Vaginal yeast infection
  • Rash
Call 911Swelling of the face, lips, or throat, hives, or trouble breathing
Call 911A blistering, peeling, or widespread red rash, especially with fever
Call your provider todaySevere watery or bloody diarrhea, even weeks after finishing (possible C. diff infection)
Call your provider todayYellow skin or eyes or dark urine

Warnings

  • Don't take it if you're allergic to penicillin. Tell your provider about any past reaction to antibiotics.
  • Tell your provider if you've had liver problems with this medicine before.

Other medicines, foods, and alcohol

  • It can increase the effect of warfarin.
  • Allopurinol increases the chance of a rash.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Commonly used in pregnancy when needed.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember. If it's almost time for the next dose, skip the missed one. Don't double up, and still finish the full course.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.