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Bempedoic acid

Brand names: Nexletol, Nexlizet (with ezetimibe)

Bempedoic acid lowers LDL cholesterol and heart attack risk. It's an option for people who can't take statins because of muscle aches.

Brand namesNexletol, Nexlizet (with ezetimibe)
Type of medicineCholesterol medicine (ACL inhibitor)
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It works in the liver, not in muscles, so it rarely causes muscle pain.

What it's used for

  • High LDL cholesterol
  • Lowering heart attack risk in people who can't take statins

How to take it

  • Take it once a day, with or without food.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Higher uric acid
  • Muscle spasms
  • Back pain
Call your provider todaySudden painful, swollen joint (gout)
Call your provider todayPain, swelling, or a pop in a tendon

Warnings

  • Tell your provider about past gout or tendon problems.

Other medicines, foods, and alcohol

  • It raises simvastatin and pravastatin levels; doses are limited.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Talk with your provider.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.