Health information to help you understand symptoms. It isn't a diagnosis.
Check symptoms

Betamethasone cream

Brand names: Diprolene, Luxiq, Sernivo, Lotrisone (with clotrimazole)

Betamethasone is a strong steroid cream, ointment, or foam for psoriasis, eczema, and inflamed skin.

Brand namesDiprolene, Luxiq, Sernivo, Lotrisone (with clotrimazole)
Type of medicineTopical steroid (strong)
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

Some forms are among the strongest topical steroids.

What it's used for

  • Psoriasis
  • Eczema
  • Other inflammatory rashes

How to take it

  • Apply a thin layer to the affected skin, usually once or twice a day, for the time your provider sets.
  • Avoid the face, groin, and armpits unless your provider says to. Wash your hands after.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Burning
  • Itching
  • Dryness
Call your provider todayThin, shiny skin, stretch marks, or easy bruising where used
Call your provider todayRash getting worse, oozing, or pus

Warnings

  • Use the shortest time that works.
  • Lotrisone (with an antifungal) isn't for diaper rash.

Other medicines, foods, and alcohol

  • Avoid other steroid creams on the same area.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Ask your provider.

Missed doses, overdose, and storage

If you miss a dose

Apply it when you remember, then go back to your usual schedule. Don't apply extra to make up for it.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.