ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.
Overview
It works similarly to aripiprazole.
What it's used for
- Add-on treatment for depression
- Schizophrenia
- Agitation with Alzheimer's dementia
How to take it
- Take it once a day, with or without food.
Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.
Side effects
Common side effects
- Weight gain
- Restlessness
- Sleepiness
- Headache
Call 911Thoughts of suicide or harming yourself. Call or text 988 any time.
Call 911High fever, stiff muscles, and confusion (NMS)
Call your provider todayUncontrolled movements
Call your provider todayStrong urges you can't control, like gambling
Warnings
- Boxed warnings: higher risk of death in older adults with dementia-related psychosis, and suicidal thoughts in young people.
Other medicines, foods, and alcohol
- Strong CYP2D6 or CYP3A4 blockers raise its level; rifampin lowers it.
Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.
Pregnancy and breastfeeding
Talk with your provider.
Missed doses, overdose, and storage
If you miss a dose
Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.
If someone takes too much
Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.
Storing it
Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.
Conditions it's used for
Sources
- DailyMed: FDA drug label for Brexpiprazole (U.S. National Library of Medicine)
- MedlinePlus: Drugs, herbs, and supplements
- FDA: Drugs@FDA
Last updated 2026-11-13.