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Bupropion

Brand names: Wellbutrin SR, Wellbutrin XL, Zyban, Aplenzin

Bupropion is an antidepressant that also helps people quit smoking. It's less likely than many antidepressants to cause weight gain or sexual side effects.

Brand namesWellbutrin SR, Wellbutrin XL, Zyban, Aplenzin
Type of medicineAntidepressant (NDRI)
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It affects dopamine and norepinephrine rather than serotonin.

What it's used for

  • Depression
  • Seasonal depression (prevention)
  • Quitting smoking (Zyban)

How to take it

  • Take it in the morning; taking it late in the day can cause trouble sleeping.
  • Swallow tablets whole. Never crush, chew, or split them.
  • Never take extra doses; this raises seizure risk.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Dry mouth
  • Trouble sleeping
  • Headache
  • Nausea
  • Feeling jittery
  • Weight loss
Call 911A seizure
Call 911Thoughts of suicide or harming yourself. Call or text 988 any time.
Call your provider todaySevere agitation, hostility, or unusual behavior
Call your provider todayEye pain, vision changes, or swelling around the eye

Warnings

  • Not for people with seizures, eating disorders like anorexia or bulimia, or who are suddenly stopping alcohol, benzodiazepines, or seizure medicines.
  • It can raise blood pressure.

Other medicines, foods, and alcohol

  • Never take within 14 days of an MAOI.
  • Don't take with other bupropion products.
  • It raises levels of some medicines, including certain antidepressants, metoprolol, and some antipsychotics. It can make tamoxifen less effective.
  • Limit or avoid alcohol.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Talk with your provider about benefits and risks.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.