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Canagliflozin

Brand names: Invokana, Invokamet (with metformin)

Canagliflozin lowers blood sugar in type 2 diabetes by helping the kidneys remove sugar. It also protects the heart and kidneys.

Brand namesInvokana, Invokamet (with metformin)
Type of medicineSGLT2 inhibitor
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It lowers the risk of heart attack, stroke, and kidney decline in people with type 2 diabetes.

What it's used for

  • Type 2 diabetes
  • Lowering heart and kidney risks in type 2 diabetes

How to take it

  • Take it once a day before the first meal.
  • Drink enough fluids.
  • Your provider may have you stop it a few days before surgery.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Genital yeast infections
  • Urinary tract infections
  • Peeing more
Call 911Nausea, vomiting, belly pain, and trouble breathing (possible ketoacidosis)
Call 911Pain, redness, or swelling in the genital area with fever
Call your provider todaySores or infections on the feet or legs
Call your provider todayDizziness or very little urine

Warnings

  • Not for type 1 diabetes.
  • Check your feet daily; it has been linked to a higher risk of toe and foot amputations in some studies.

Other medicines, foods, and alcohol

  • Rifampin and some seizure medicines lower its effect.
  • It can raise digoxin levels.
  • Insulin and sulfonylureas may need lower doses.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Not recommended in the second and third trimesters or while breastfeeding.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.