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Capsaicin cream and patch

Brand names: Zostrix, Qutenza (high-dose patch)

Capsaicin, from chili peppers, reduces pain signals when used regularly on the skin. It helps arthritis and nerve pain.

Brand namesZostrix, Qutenza (high-dose patch)
Type of medicineTopical pain reliever
Prescription?Over the counter (cream); prescription (8% patch)
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It burns at first; the burning fades with regular use over 1 to 2 weeks.

What it's used for

  • Arthritis pain
  • Nerve pain after shingles
  • Diabetic nerve pain in the feet (patch)

How to take it

  • Apply a thin layer 3 to 4 times a day to unbroken skin.
  • Wash your hands well after, and don't touch your eyes.
  • Don't use heat on the area.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Burning, stinging, and redness
Call your provider todaySevere burning or blistering

Warnings

  • Keep away from eyes and broken skin.

Other medicines, foods, and alcohol

  • None known.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Ask your provider.

Missed doses, overdose, and storage

If you miss a dose

Apply it when you remember, then go back to your usual schedule. Don't apply extra to make up for it.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.