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Chlorpromazine

Brand names: Thorazine (brand discontinued)

Chlorpromazine is an older antipsychotic also used for severe nausea, hiccups that won't stop, and agitation.

Brand namesThorazine (brand discontinued)
Type of medicineAntipsychotic (first generation)
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It's quite sedating.

What it's used for

  • Schizophrenia
  • Severe nausea and vomiting
  • Hiccups that won't stop
  • Agitation

How to take it

  • Take it as prescribed. Stand up slowly.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Sleepiness
  • Dizziness
  • Dry mouth
  • Sun sensitivity
Call 911High fever, stiff muscles, confusion, and sweating (rare reaction called NMS)
Call your provider todayUncontrolled movements of the face, tongue, or body
Call 911Fainting or a fast, irregular heartbeat
Call your provider todayYellow skin or fever with sore throat

Warnings

  • Boxed warning: higher risk of death in older adults with dementia.

Other medicines, foods, and alcohol

  • Alcohol and sedating medicines add to drowsiness.
  • It works against Parkinson's medicines.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Talk with your provider.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.