ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.
Overview
It binds bile acids in the gut.
What it's used for
- High LDL cholesterol
- Itching from blocked bile flow
- Off-label: bile acid diarrhea
How to take it
- Mix the powder with water or juice; don't take it dry.
- Take other medicines at least 1 hour before or 4 to 6 hours after.
Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.
Side effects
Common side effects
- Constipation
- Bloating
- Gas
Call your provider todaySevere constipation or belly pain
Warnings
- It can lower absorption of vitamins A, D, E, and K.
Other medicines, foods, and alcohol
- It blocks absorption of many medicines, including levothyroxine, warfarin, and digoxin.
Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.
Pregnancy and breastfeeding
Talk with your provider.
Missed doses, overdose, and storage
If you miss a dose
Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.
If someone takes too much
Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.
Storing it
Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.
Conditions it's used for
Sources
- DailyMed: FDA drug label for Cholestyramine (U.S. National Library of Medicine)
- MedlinePlus: Drugs, herbs, and supplements
- FDA: Drugs@FDA
Last updated 2026-11-13.