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Cilostazol

Brand names: Pletal (brand discontinued)

Cilostazol improves walking distance in people with leg pain from poor circulation (claudication).

Brand namesPletal (brand discontinued)
Type of medicineCirculation medicine
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It takes 2 to 12 weeks to work.

What it's used for

  • Leg pain when walking from peripheral artery disease

How to take it

  • Take it twice a day, 30 minutes before or 2 hours after breakfast and dinner.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Headache
  • Diarrhea
  • Fast heartbeat
  • Dizziness
Call 911Chest pain or a fast, irregular heartbeat
Call your provider todayShortness of breath or swelling (heart failure)
Call your provider todayUnusual bleeding

Warnings

  • Boxed warning: never use with heart failure of any severity.

Other medicines, foods, and alcohol

  • Diltiazem, omeprazole, some antifungals, and grapefruit juice raise its level.
  • Aspirin and blood thinners raise bleeding risk.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Talk with your provider.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.