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Clindamycin

Brand names: Cleocin, Clindagel

Clindamycin is an antibiotic for skin, bone, dental, and some other infections, often in people allergic to penicillin. Gels and lotions treat acne.

Brand namesCleocin, Clindagel
Type of medicineAntibiotic
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

Taken by mouth, it has one of the highest risks of C. diff diarrhea.

What it's used for

  • Skin infections and abscesses, including some MRSA
  • Dental infections
  • Bone and joint infections
  • Bacterial vaginosis (cream)
  • Acne (gel or lotion)

How to take it

  • Take capsules with a full glass of water to avoid throat irritation.
  • Finish the full course.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Diarrhea
  • Nausea
  • Metallic taste
Call your provider todayWatery or bloody diarrhea, even up to 2 months after finishing. Don't take anti-diarrhea medicine; call your provider.
Call 911Swelling of the face, lips, or throat, hives, or trouble breathing
Call 911A blistering, peeling, or widespread red rash, especially with fever

Warnings

  • Boxed warning: C. diff infection, which can be severe.

Other medicines, foods, and alcohol

  • Erythromycin can block its effect.
  • Some medicines (like rifampin) lower its level.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Can be used in pregnancy when needed.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember. If it's almost time for the next dose, skip the missed one. Don't double up, and still finish the full course.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.