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Clobazam

Brand names: Onfi, Sympazan

Clobazam is a benzodiazepine used with other medicines for Lennox-Gastaut syndrome seizures.

Brand namesOnfi, Sympazan
Type of medicineBenzodiazepine (seizure medicine)
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It's a controlled substance.

What it's used for

  • Seizures in Lennox-Gastaut syndrome
  • Off-label: other epilepsies

How to take it

  • Take it as prescribed. Don't stop suddenly.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Sleepiness
  • Drooling
  • Irritability
  • Fever
Call 911Slow, shallow, or stopped breathing, blue lips, or can't be woken up
Call 911A blistering, peeling, or widespread red rash, especially with fever
Call 911Thoughts of suicide or harming yourself. Call or text 988 any time.

Warnings

  • Boxed warnings: misuse and dependence; deadly risk with opioids.

Other medicines, foods, and alcohol

  • Taking it with opioids, alcohol, or other sedating medicines can slow breathing and cause death.
  • It makes hormonal birth control less effective.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Talk with your provider.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.