Overview
It's in many nighttime cold products.
What it's used for
- Occasional trouble sleeping
- Morning sickness (with vitamin B6)
How to take it
- Sleep aid: take 30 minutes before bed, only occasionally.
- Pregnancy nausea: follow your prescription, often at bedtime, swallowed whole on an empty stomach.
Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.
Side effects
Common side effects
- Drowsiness
- Dry mouth
- Dizziness
- Constipation
Warnings
- Don't drive after taking it.
- Older adults are more likely to become confused or fall.
Other medicines, foods, and alcohol
- Alcohol and sedating medicines add to drowsiness.
- Never take within 14 days of an MAOI.
Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.
Pregnancy and breastfeeding
The prescription combination with B6 is approved for nausea and vomiting of pregnancy.
Missed doses, overdose, and storage
If you miss a dose
As a sleep aid, take it only at bedtime. For pregnancy nausea, follow your prescription and don't double up.
If someone takes too much
Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.
Storing it
Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.
Conditions it's used for
Sources
- DailyMed: FDA drug label for Doxylamine (U.S. National Library of Medicine)
- MedlinePlus: Drugs, herbs, and supplements
- FDA: Drugs@FDA
Last updated 2026-11-13.