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Dulaglutide

Brand names: Trulicity

Dulaglutide (Trulicity) is a once-weekly shot that lowers blood sugar in type 2 diabetes and lowers heart risk.

Brand namesTrulicity
Type of medicineGLP-1 receptor agonist
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It acts like a gut hormone that boosts insulin when sugar is high and slows stomach emptying.

What it's used for

  • Type 2 diabetes
  • Lowering the risk of heart attack and stroke in people with type 2 diabetes

How to take it

  • Inject once a week on the same day, under the skin of the belly, thigh, or upper arm.
  • Eat smaller meals and stop when full.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Nausea
  • Diarrhea
  • Vomiting
  • Less appetite
  • Stomach pain
Call 911Severe belly pain that spreads to the back, with or without vomiting (possible pancreatitis)
Call your provider todayVomiting or diarrhea that won't let you keep fluids down
Call your provider todayPain in the upper right belly, fever, or yellow skin (gallbladder)
Call your provider todayA lump in the neck, trouble swallowing, or hoarseness

Warnings

  • Not for people with a personal or family history of medullary thyroid cancer or MEN 2.
  • Tell anyone giving you anesthesia that you take it.

Other medicines, foods, and alcohol

  • Insulin and sulfonylureas raise the risk of low blood sugar.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Talk with your provider before pregnancy.

Missed doses, overdose, and storage

If you miss a dose

Take it if your next dose is at least 3 days (72 hours) away. Otherwise skip it and take the next dose on your usual day.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.