ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.
Overview
It blocks factor Xa and doesn't need regular INR tests.
What it's used for
- Lowering stroke risk in AFib
- Treating clots in the legs or lungs
How to take it
- Take it once a day, with or without food.
- Don't stop without asking your provider.
- Tell every provider and dentist you take it.
Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.
Side effects
Common side effects
- Bruising
- Minor bleeding
Call 911Vomiting blood, coughing up blood, or bleeding that won't stop
Call 911Sudden weakness, trouble speaking, or a severe headache
Call your provider todayBlack or bloody stools, or pink or brown urine
Warnings
- Boxed warnings: stopping early raises stroke risk; spinal bleeding with spinal procedures; it works less well in AFib when kidney function is very good.
Other medicines, foods, and alcohol
- Aspirin, NSAIDs, other blood thinners, and SSRIs raise bleeding risk.
- Rifampin lowers its effect.
Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.
Pregnancy and breastfeeding
Talk with your provider.
Missed doses, overdose, and storage
If you miss a dose
Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.
If someone takes too much
Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.
Storing it
Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.
Conditions it's used for
Sources
- DailyMed: FDA drug label for Edoxaban (U.S. National Library of Medicine)
- MedlinePlus: Drugs, herbs, and supplements
- FDA: Drugs@FDA
Last updated 2026-11-13.