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Epinephrine auto-injector

Brand names: EpiPen, Auvi-Q, Adrenaclick, neffy (nasal spray)

Epinephrine is the emergency treatment for a severe allergic reaction (anaphylaxis). Use it right away, then call 911.

Brand namesEpiPen, Auvi-Q, Adrenaclick, neffy (nasal spray)
Type of medicineEmergency allergy medicine
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It quickly opens the airways, raises blood pressure, and reduces swelling.

Antihistamines like Benadryl don't replace it.

What it's used for

  • Severe allergic reactions to foods, insect stings, medicines, or latex

How to take it

  • At the first signs of a severe reaction (trouble breathing, throat tightness, swelling of the lips or tongue, widespread hives with vomiting, or fainting), use it in the outer thigh. It can go through clothing.
  • Call 911 every time, even if the person feels better.
  • If symptoms don't improve in 5 to 15 minutes, a second dose may be given.
  • Carry two at all times and check expiration dates. Teach family, friends, and school staff how to use it.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Fast heartbeat
  • Shakiness
  • Anxiety
  • Pale skin
  • Headache
Call 911Anyone who needed epinephrine should be checked in the emergency room. Symptoms can come back hours later.
Call your provider todayRedness, swelling, or warmth where it was injected (possible infection)

Warnings

  • There's no reason not to use it in a true anaphylaxis emergency.
  • Don't inject into the hands, feet, or buttocks.

Other medicines, foods, and alcohol

  • Some heart and blood pressure medicines (like beta blockers) can make it work less well; still use it.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Use it for anaphylaxis in pregnancy; the reaction is far more dangerous than the medicine.

Missed doses, overdose, and storage

If you miss a dose

Not applicable: epinephrine is used only in an emergency.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Keep at room temperature, out of direct sun, and not in a car. Check the window; replace it if the liquid is cloudy or brown, or it's expired.

Conditions it's used for

Sources

Last updated 2026-11-13.