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Eplerenone

Brand names: Inspra

Eplerenone blocks the hormone aldosterone. It treats heart failure after a heart attack and high blood pressure.

Brand namesInspra
Type of medicinePotassium-sparing diuretic
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It's similar to spironolactone but less likely to cause breast swelling.

What it's used for

  • Heart failure after a heart attack
  • Heart failure
  • High blood pressure

How to take it

  • Take it with or without food.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Dizziness
  • High potassium
  • Cough
  • Diarrhea
Call 911A slow or irregular heartbeat or muscle weakness (high potassium)
Call your provider todayPeeing much less

Warnings

  • Your provider will check potassium and kidney function.

Other medicines, foods, and alcohol

  • Strong antifungals and some antibiotics raise its level.
  • Potassium supplements, ACE inhibitors, ARBs, and NSAIDs raise potassium.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Talk with your provider.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.