ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.
Overview
You're monitored for at least 2 hours after each dose and can't drive that day.
What it's used for
- Treatment-resistant depression
- Depression with suicidal thoughts (with an oral antidepressant)
How to take it
- Used in a clinic under supervision, usually twice weekly at first.
- Arrange a ride home.
Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.
Side effects
Common side effects
- Dissociation (feeling detached)
- Dizziness
- Nausea
- Higher blood pressure for a few hours
Call 911Thoughts of suicide or harming yourself. Call or text 988 any time.
Call your provider todayVery high blood pressure or chest pain after a session
Warnings
- Boxed warnings: sedation, dissociation, misuse, and suicidal thoughts.
Other medicines, foods, and alcohol
- Other sedating medicines add to drowsiness.
- Stimulants and MAOIs can raise blood pressure.
Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.
Pregnancy and breastfeeding
Not used in pregnancy.
Missed doses, overdose, and storage
If you miss a dose
Call the clinic to reschedule.
If someone takes too much
Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.
Storing it
Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.
Conditions it's used for
Sources
- DailyMed: FDA drug label for Esketamine (U.S. National Library of Medicine)
- MedlinePlus: Drugs, herbs, and supplements
- FDA: Drugs@FDA
Last updated 2026-11-13.