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Evolocumab

Brand names: Repatha

Evolocumab is a cholesterol-lowering shot given every 2 weeks or monthly. It lowers LDL cholesterol a lot.

Brand namesRepatha
Type of medicinePCSK9 inhibitor (cholesterol medicine)
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It's used when statins aren't enough or aren't tolerated.

What it's used for

  • High LDL cholesterol
  • Lowering heart attack and stroke risk in heart disease
  • Inherited high cholesterol

How to take it

  • Inject under the skin of the belly, thigh, or upper arm.
  • Let it warm to room temperature first.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Stuffy nose or cold symptoms
  • Back pain
  • Injection site reactions
Call 911Swelling of the face, lips, or throat, hives, or trouble breathing

Warnings

  • Usually used with a statin and healthy diet.

Other medicines, foods, and alcohol

  • Few interactions.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Talk with your provider.

Missed doses, overdose, and storage

If you miss a dose

Every-2-weeks dose: take it within 7 days, then keep your schedule; after 7 days, skip it. Monthly dose: take it within 7 days and start a new schedule from that date; ask your provider if later.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Keep in the refrigerator in the original carton. It can be kept at room temperature for up to 30 days.

Conditions it's used for

Sources

Last updated 2026-11-13.