Febuxostat (Uloric): Uses, Side Effects, and Warnings

ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

Gout flares may increase in the first months; a flare-prevention medicine is often added.

What it's used for

Preventing gout attacks

How to take it

Take it once a day, with or without food.
Keep taking it during a flare.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

Gout flares at first
Nausea
Joint pain
Rash

Call 911Chest pain, shortness of breath, or signs of a stroke

Call your provider todayYellow skin or eyes or dark urine

Call 911A blistering, peeling, or widespread red rash, especially with fever

Warnings

Boxed warning: higher risk of heart-related death than allopurinol in people with heart disease.

Other medicines, foods, and alcohol

Never take with azathioprine or mercaptopurine.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Talk with your provider.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Gout

Sources

Last updated 2026-11-13.

Febuxostat