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Fluticasone, umeclidinium, and vilanterol

Brand names: Trelegy Ellipta

Trelegy is a once-daily inhaler that combines a steroid and two long-acting bronchodilators for COPD and asthma.

Brand namesTrelegy Ellipta
Type of medicineTriple therapy inhaler
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It's used when symptoms or flare-ups continue on two-medicine inhalers.

What it's used for

  • COPD
  • Asthma

How to take it

  • Use one inhalation once a day.
  • Rinse your mouth and spit after.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Headache
  • Back pain
  • Hoarse voice
  • Thrush
Call 911Breathing gets worse right after using it
Call 911Chest pain or a fast, irregular heartbeat
Call your provider todayNeeding your rescue inhaler more often
Call your provider todayFever, cough with mucus, or chest pain (possible pneumonia)
Call your provider todayEye pain or trouble peeing

Warnings

  • Long-term steroid use can affect bones and eyes.

Other medicines, foods, and alcohol

  • Ritonavir and ketoconazole raise steroid levels.
  • Avoid other anticholinergic inhalers.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Talk with your provider.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.