Health information to help you understand symptoms. It isn't a diagnosis.
Check symptoms

Guaifenesin

Brand names: Mucinex, Robitussin Chest Congestion

Guaifenesin thins mucus so it's easier to cough up. It's in many cold medicines.

Brand namesMucinex, Robitussin Chest Congestion
Type of medicineExpectorant (cough medicine)
Prescription?Over the counter
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

Drinking plenty of fluids helps it work. Many combination products also contain other medicines.

What it's used for

  • Chest congestion from colds and bronchitis

How to take it

  • Take it with a full glass of water.
  • Swallow extended-release tablets whole.
  • Check labels so you don't double up on other ingredients.
  • Don't give cough and cold medicines to children under 4.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Nausea
  • Dizziness
  • Headache
Call 911Trouble breathing
Call your provider todayCough lasting more than 7 days, or with high fever, rash, or a lasting headache

Warnings

  • Ask a provider for a cough from smoking, asthma, or COPD, or with lots of mucus.

Other medicines, foods, and alcohol

  • Few interactions on its own; check other ingredients in combination products.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Ask your provider before using it in pregnancy.

Missed doses, overdose, and storage

If you miss a dose

This medicine is often taken only when needed. If you take it on a schedule, take a missed dose when you remember, unless it's almost time for the next one. Don't double up.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.