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Hemorrhoid creams and suppositories

Brand names: Preparation H, Anusol-HC, Tucks, Proctofoam

Hemorrhoid creams, ointments, wipes, and suppositories ease itching, swelling, and pain from hemorrhoids.

Brand namesPreparation H, Anusol-HC, Tucks, Proctofoam
Type of medicineHemorrhoid treatments
Prescription?Over the counter (hydrocortisone 2.5% by prescription)
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

Many combine a protectant, a numbing medicine, a shrinking agent (phenylephrine), witch hazel, or hydrocortisone.

What it's used for

  • Hemorrhoid itching, pain, and swelling
  • Anal fissure discomfort

How to take it

  • Gently clean and dry the area, then apply as the label says.
  • Use hydrocortisone products for no more than 1 week unless told otherwise.
  • Add fiber and fluids and avoid straining.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Burning or irritation
Call your provider todayHeavy bleeding, black stools, or bleeding with dizziness
Call your provider todaySevere pain or a hard, purple lump (possible clot)

Warnings

  • Rectal bleeding should be checked, especially after age 45 or with bowel changes.

Other medicines, foods, and alcohol

  • Phenylephrine products: ask first if you take MAOIs or have high blood pressure.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Ask your provider.

Missed doses, overdose, and storage

If you miss a dose

This medicine is often taken only when needed. If you take it on a schedule, take a missed dose when you remember, unless it's almost time for the next one. Don't double up.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.