ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.
Overview
Results take a few months; sunscreen every day is essential.
What it's used for
- Melasma and dark spots
How to take it
- Apply a thin layer to dark spots, usually twice a day.
- Use for a limited time, often 3 to 4 months, then take a break.
Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.
Side effects
Common side effects
- Mild irritation
- Redness
Call your provider todayBlue-black darkening of the skin (ochronosis) with long use
Call your provider todaySevere irritation
Warnings
- Over-the-counter hydroquinone was removed from U.S. shelves in 2020; it's now prescription only.
Other medicines, foods, and alcohol
- Don't use with benzoyl peroxide or peroxide products at the same time.
Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.
Pregnancy and breastfeeding
Not recommended in pregnancy.
Missed doses, overdose, and storage
If you miss a dose
Apply it when you remember, then go back to your usual schedule. Don't apply extra to make up for it.
If someone takes too much
Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.
Storing it
Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.
Conditions it's used for
Sources
- DailyMed: FDA drug label for Hydroquinone (U.S. National Library of Medicine)
- MedlinePlus: Drugs, herbs, and supplements
- FDA: Drugs@FDA
Last updated 2026-11-13.