ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.
Overview
It isn't the same as over-the-counter fish oil supplements.
What it's used for
- Very high triglycerides
- Lowering heart attack and stroke risk in some people with high triglycerides on a statin
How to take it
- Take capsules with food, swallowed whole.
Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.
Side effects
Common side effects
- Joint pain
- Constipation
- Swelling in the legs
Call your provider todayA fast, fluttering, or irregular heartbeat (AFib)
Call your provider todayUnusual bleeding or bruising
Warnings
- Tell your provider if you're allergic to fish or shellfish.
Other medicines, foods, and alcohol
- Blood thinners and antiplatelets may add to bleeding risk.
Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.
Pregnancy and breastfeeding
Talk with your provider.
Missed doses, overdose, and storage
If you miss a dose
Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.
If someone takes too much
Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.
Storing it
Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.
Conditions it's used for
Sources
- DailyMed: FDA drug label for Icosapent ethyl (U.S. National Library of Medicine)
- MedlinePlus: Drugs, herbs, and supplements
- FDA: Drugs@FDA
Last updated 2026-11-13.