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Levetiracetam

Brand names: Keppra, Spritam

Levetiracetam is a widely used seizure medicine for several kinds of epilepsy.

Brand namesKeppra, Spritam
Type of medicineAnticonvulsant (seizure medicine)
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It has few drug interactions. Doses are lower for people with kidney disease.

What it's used for

  • Partial (focal) seizures
  • Myoclonic seizures
  • Generalized tonic-clonic seizures

How to take it

  • Take it twice a day (or once a day for extended-release), with or without food.
  • Swallow tablets whole.
  • Don't stop suddenly; this can trigger seizures.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Sleepiness
  • Weakness
  • Dizziness
  • Irritability
Call 911Seizures happening more often or a long seizure
Call 911Thoughts of suicide or harming yourself. Call or text 988 any time.
Call your provider todayAnger, aggression, anxiety, or mood changes (more common with this medicine)
Call 911A blistering, peeling, or widespread red rash, especially with fever

Warnings

  • Don't drive until you know how it affects you and your seizures are controlled per your state's rules.
  • Mood and behavior changes are a known side effect; tell your provider.

Other medicines, foods, and alcohol

  • Alcohol and sedating medicines add to drowsiness.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Commonly used in pregnancy. Don't stop on your own; talk with your provider.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.