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Linagliptin

Brand names: Tradjenta, Jentadueto (with metformin)

Linagliptin helps the body release more insulin after meals to lower blood sugar in type 2 diabetes.

Brand namesTradjenta, Jentadueto (with metformin)
Type of medicineDPP-4 inhibitor (diabetes medicine)
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It doesn't need a dose change for kidney disease. On its own, it rarely causes low blood sugar.

What it's used for

  • Type 2 diabetes

How to take it

  • Take it once a day, with or without food.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Stuffy nose or sore throat
  • Cough
  • Diarrhea
Call 911Severe belly pain that spreads to the back (possible pancreatitis)
Call 911Swelling of the face, lips, or throat, hives, or trouble breathing
Call your provider todaySevere joint pain
Call your provider todayBlisters on the skin

Warnings

  • Not for type 1 diabetes.

Other medicines, foods, and alcohol

  • Insulin and sulfonylureas may need lower doses.
  • Rifampin lowers its effect.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Talk with your provider.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.