Overview
It's an option for people who want to avoid long-term antibiotics. It doesn't treat an active infection.
What it's used for
- Preventing frequent UTIs
How to take it
- Take it twice a day (hippurate form).
- Avoid large amounts of antacids and citrus juices that make urine less acidic.
Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.
Side effects
Common side effects
- Nausea
- Upset stomach
- Rash
Warnings
- Not for people with severe kidney or liver disease or dehydration.
Other medicines, foods, and alcohol
- Sulfa antibiotics shouldn't be taken with it.
- Antacids and bicarbonate make it less effective.
Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.
Pregnancy and breastfeeding
Ask your provider.
Missed doses, overdose, and storage
If you miss a dose
Take it as soon as you remember. If it's almost time for the next dose, skip the missed one. Don't double up, and still finish the full course.
If someone takes too much
Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.
Storing it
Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.
Conditions it's used for
Sources
- DailyMed: FDA drug label for Methenamine (U.S. National Library of Medicine)
- MedlinePlus: Drugs, herbs, and supplements
- FDA: Drugs@FDA
Last updated 2026-11-13.