Health information to help you understand symptoms. It isn't a diagnosis.
Check symptoms

Niacin (prescription)

Brand names: Niaspan, Niacor

Prescription niacin raises HDL and lowers triglycerides and LDL. It's now used less often because studies didn't show fewer heart attacks when added to statins.

Brand namesNiaspan, Niacor
Type of medicineVitamin B3 (cholesterol medicine)
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

Over-the-counter niacin supplements aren't the same and shouldn't be used to treat cholesterol without guidance.

What it's used for

  • High triglycerides
  • High cholesterol when other medicines aren't enough

How to take it

  • Take it at bedtime after a low-fat snack.
  • Taking aspirin 30 minutes before (if your provider agrees) can reduce flushing.
  • Avoid hot drinks and alcohol near your dose.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Flushing, warmth, and itching
  • Upset stomach
  • Higher blood sugar
Call your provider todayYellow skin or eyes or dark urine
Call your provider todayUnexplained muscle pain or weakness
Call your provider todaySudden painful, swollen joint (gout)

Warnings

  • Don't switch between niacin products; dose-for-dose differences can cause liver damage.

Other medicines, foods, and alcohol

  • Statins add to the risk of muscle problems.
  • Diabetes medicines may need adjusting.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Not used for cholesterol in pregnancy.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.