Health information to help you understand symptoms. It isn't a diagnosis.
Check symptoms

Oxymetazoline nasal spray

Brand names: Afrin, Vicks Sinex

Oxymetazoline (Afrin) nasal spray quickly opens a stuffy nose for up to 12 hours. Using it more than 3 days can cause rebound congestion.

Brand namesAfrin, Vicks Sinex
Type of medicineDecongestant nasal spray
Prescription?Over the counter
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

Rebound congestion (rhinitis medicamentosa) makes people feel they can't stop using it.

What it's used for

  • Short-term stuffy nose from colds, allergies, or sinus infections
  • Nosebleeds (in clinics)

How to take it

  • Use no more than twice a day and no longer than 3 days.
  • Don't share the bottle.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Burning or stinging
  • Sneezing
  • Rebound stuffiness
Call your provider todayFast heartbeat or very high blood pressure

Warnings

  • Not for children under 6 unless a provider says to.

Other medicines, foods, and alcohol

  • Never take within 14 days of an MAOI.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Ask your provider.

Missed doses, overdose, and storage

If you miss a dose

This medicine is often taken only when needed. If you take it on a schedule, take a missed dose when you remember, unless it's almost time for the next one. Don't double up.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.