Health information to help you understand symptoms. It isn't a diagnosis.
Check symptoms

Pancrelipase

Brand names: Creon, Zenpep, Pancreaze, Viokace

Pancrelipase replaces the digestive enzymes your pancreas isn't making, helping you absorb fat and nutrients.

Brand namesCreon, Zenpep, Pancreaze, Viokace
Type of medicinePancreatic enzymes
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It's used in cystic fibrosis, chronic pancreatitis, and after pancreas surgery.

What it's used for

  • Exocrine pancreatic insufficiency (EPI)

How to take it

  • Take it with every meal and snack, at the first bite.
  • Swallow capsules whole, or open and sprinkle on applesauce; don't crush or chew the beads.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Belly pain
  • Gas
  • Headache
Call your provider todaySevere belly pain, bloating, or vomiting (rare bowel narrowing with very high doses)
Call your provider todayJoint pain or swelling (high uric acid)

Warnings

  • Don't change brands or doses without asking.

Other medicines, foods, and alcohol

  • Acid reducers may be added to help it work.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Talk with your provider.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.