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Prochlorperazine

Brand names: Compazine (brand discontinued), Compro

Prochlorperazine treats severe nausea and vomiting. In the ER it's also used for migraines.

Brand namesCompazine (brand discontinued), Compro
Type of medicineAnti-nausea medicine (phenothiazine)
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

It can cause restlessness or muscle spasms, especially in young people.

What it's used for

  • Severe nausea and vomiting
  • Migraine (in the ER)
  • Anxiety (short term)

How to take it

  • Take it as prescribed; suppositories are available if you can't keep pills down.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Sleepiness
  • Dizziness
  • Dry mouth
  • Restlessness
Call your provider todayMuscle spasms of the neck, jaw, or eyes
Call 911High fever, stiff muscles, and confusion (NMS)
Call your provider todayUncontrolled movements

Warnings

  • Boxed warning: higher risk of death in older adults with dementia.
  • Not for children under 2 or under 20 pounds.

Other medicines, foods, and alcohol

  • Alcohol and sedating medicines add to drowsiness.
  • It works against Parkinson's medicines.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Talk with your provider.

Missed doses, overdose, and storage

If you miss a dose

This medicine is often taken only when needed. If you take it on a schedule, take a missed dose when you remember, unless it's almost time for the next one. Don't double up.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.