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Pyridostigmine

Brand names: Mestinon

Pyridostigmine improves muscle strength in myasthenia gravis.

Brand namesMestinon
Type of medicineCholinesterase inhibitor
Prescription?Prescription
ImportantThis page is general information, not a prescription. Don't start, stop, or change a medicine without talking to your provider or pharmacist.

Overview

Effects last a few hours, so doses are timed around activities and meals.

What it's used for

  • Myasthenia gravis
  • Off-label: dizziness when standing and POTS

How to take it

  • Take it as prescribed, often 30 to 60 minutes before meals.

Your dose depends on your health and other medicines. Always follow your prescription label, and ask your pharmacist if anything is unclear.

Side effects

Common side effects

  • Stomach cramps
  • Diarrhea
  • Sweating
  • Muscle twitching
Call 911Trouble breathing or swallowing (myasthenic or cholinergic crisis)

Warnings

  • Too much can cause weakness similar to the disease.

Other medicines, foods, and alcohol

  • Some antibiotics and beta blockers can worsen myasthenia.

Tell your provider and pharmacist about every medicine, vitamin, and supplement you take.

Pregnancy and breastfeeding

Talk with your provider.

Missed doses, overdose, and storage

If you miss a dose

Take it as soon as you remember, unless it's almost time for your next dose. Then skip the missed dose. Don't take two doses at once.

If someone takes too much

Call Poison Control at 1-800-222-1222 or get help online at poison.org. Call 911 if the person collapses, has a seizure, has trouble breathing, or can't be woken.

Storing it

Store at room temperature, away from heat and moisture (not in the bathroom), and out of reach of children and pets.

Conditions it's used for

Sources

Last updated 2026-11-13.